Sasaki Lab | Fukushima Medical University　　Japanese/English

Publications

• Abnormal Michael Reaction: Conditions-Dependent Product Distributions in the Michael Reaction of Monoalkyl-Substituted Malonates
• • Michiko Sasaki, Akitomo Kasahara, Kei Takeda
  • J. Org. Chem. 89, 4923-4931 (2024)
  
  
• Steric Course of Deprotonation/Substitution of Chelating/Dipole-Stabilizing Group-Substituted α-Amino- and α-Oxynitriles
• • Michiko Sasaki, Rumiko Shimabara, Takegawa Tomo, Kotomori Yuri, Otani Yuko, Ohwada Tomohiko, Takeda Kei
  • Eur. J. Org. Chem. 30, 4128-4134 (2018)
  
  
• [2 + 2 + 2] Cycloaddition Strategy for the Synthesis of Pyridines: Intramolecular Propargylic Ene Reaction/Aza Diels–Alder Reaction Cascades
• • Michiko Sasaki, Philip J. Hamzik, Hidaka Ikemoto, Samuel G. Bartko, Rick L. Danheiser
  • Org. Lett. 20, 6244-6249 (2018)
  
  
• Computation-Assisted Disconnection Approach for the Synthesis of Neoantimycins, 15-Membered Macrocyclic Depsipeptides
• • Shuhei Yamakoshi, Masako Okamoto, Hiroaki Sawamoto, Yuuki Arai, Eiji Kawanishi, Michiko Sasaki, Kei Takeda
  • Curr. Org. Synth. 14, 299-308 (2017)
  
  
• Carbanion-Induced [3 + 2] Annulation of Donor-Acceptor Cyclopropanes
• • Michiko Sasaki, Yasuhiro Kondo, Takuya Nishio, Kei Takeda
  • Org. Lett. 18, 3858-3861 (2016)
  
  
• Spontaneous Oxygenation of Siloxy-N-Silylketenimines to α-Ketoamides
• • Michiko Sasaki, Masafumi Ando, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • Org. Lett. 18, 1598-1601 (2016) (Open Access)
  
  
• Inhibitory Effects of Antibiofilm Compound 1 in Staphylococcus Aureus Biofilms
• Looniva Shrestha, Shizuo Kayama, Michiko Sasaki, Fuminori Kato, Junzo Hisatune, Keiko Tsuruda, Kazuhisa Koizumi, Nobuyuki Tatsukawa, Liansheng Yu, Kei Takeda, Motoyuki Sugai
• Microbiol. Immunol. 60, 148-159 (2016)


• Stereochemical Course of Deprotonation-Acylation of N-Boc- and N-Carbamoyl-2-cyano-6-methylpiperidines
• • Yuri Kotomori, Michiko Sasaki, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • J. Org. Chem. 80,11013-11020 (2015) (Open Access)
  
  
• Brook Rearrangement
• • Michiko Sasaki, Kei Takeda
  • In Molecular Rearrangements in Organic Synthesis, Ed. Christian Rojas, Ch. 6, Wiley (2015)
  
  
• Enantioselective Synthesis of Allenylenol Silyl Ethers via Chiral Lithium Amide-Mediated Reduction of Ynenoyl Silanes and Their Diels-Alder Reactions
• • Michiko Sasaki, Yasuhiro Kondo, Ta-ichi Moto-ishi, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • Org. Lett. 17, 1280－1283 (2015)
  
  
• Formation of 2-Cyano-2-siloxyvinylallenes via Cyanide-Induced Brook Rearrangement in γ-Bromo-α,β,γ,δ-unsaturated Acylsilanes
• • Masafumi Ando, Michiko Sasaki, Izumi Miyashita, Kei Takeda
  • J. Org. Chem. 80, 247–255 (2015)
  
  
• Enantioselective Synthesis of α-Silylamines by Meerwein–Ponndorf–Verley-Type Reduction of α-Silylimines by a Chiral Lithium Amide
• • Yasuhiro Kondo, Michiko Sasaki, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • J. Org. Chem. 79, 3601–3609 (2014)
  
  
• Base-Dependent Enantiodevergent Deprotonation/Acylation of a-Amino Nitriles
• • Michiko Sasaki, Tomo Takegawa, Kunihiro Sakamoto, Yuri Kotomori, Yuko Otani,Tomohiko Ohwada, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • Synfacts (contributors: Paul Knochel, Andreas K. Steib), 10, 198–198. (2014)
  
  
• Enantiodivergent Deprotonation–Acylation of α-Amino Nitriles
• • Michiko Sasaki, Tomo Takegawa, Kunihiro Sakamoto, Yuri Kotomori, Yuko Otani,Tomohiko Ohwada, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • Angew. Chem. Int. Ed. 52, 12956–12960 (2013)
  
  
• Chirality Transfer in Brook Rearrangement-Mediated S_E2’ Solvolytic Protonation and Its Use in Estimation of the Propensity for Racemization of the α-Lithiocarbanions of the Substituents
• • Michiko Sasaki, Misato Fujiwara, Yuri Kotomora, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • Tetrahedron 69, 5823–5828 (2013)
  
  
• Synthetic Potential of Configurationally Unstable Chiral Carbanions
• • Michiko Sasaki, Kei Takeda
  • J.Synth. Org. Chem., Jpn., 71,136-148 (2013)
  
  
• Synthetic Potential of Configurationally Unstable Chiral Carbanions
• • Michiko Sasaki. Kei Takeda
  • SYNLETT (ACCOUNT, invited), 23, 2153-2164
  
  
• Enantioselective Trapping of an a-Chiral Carbanion of Acyclic Nitrile by a Carbon Electrophile
• • Michiko Sasaki, Tomo Takegawa, Hidaka Ikemoto, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • Chem. Commun. 48, 2897–2899 (2012)
  
  
　
• DISCUSSION ADDENDUM FOR: [3 + 4] Annulation Using a [β-(Trimethylsilyl)acryloyl]silane and the Lithium Enolate of an α,β-Unsaturated Methyl Ketone: (1R,6S,7S)-4-(tert-Butyldimethylsiloxy)-6-(trimethylsilyl)bicyclo[5.4.0]undec-4-en-2-one
• • Kei Takeda, Michiko Sasaki
  • Org. Synth. 89, 267–273 (2012); Original Article: Org. Synth. 76, 199 (1999)
  
  
• Steric Course of the Electrophilc Substitution of a Lithiocarbanion Generated from (S,E)-1-Phenylbut-2-en-1-yl Diisopropylcarbamate and Solvent Effects
• • Hidaka Ikemoto, Michiko Sasaki, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • Eur. J. Org. Chem. 2011, 6553–6557 (2011)
  
  
• Enantioselective Synthesis of Siloxyallenes from Alkynoyl Silanes by Reduction and a Brook Rearrangement and Their Subsequent Trapping in a [4+2] Cycloaddition
• • Michiko Sasaki, Yasuhiro Kondo, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • Angew. Chem. Int. Ed. 50, 6375–6378 (2011) (Selected by Angewandte Chemie as a Very Important Paper)
  
  
• Solvent Effects on the Steric Course of [2,3]-Wittig Rearrangement of (S,E)-(3-(allyloxy)prop-1-ene-1,3-diyl)dibenzene and Its Derivatives
• • Hidaka Ikemoto, Michiko Sasaki, Kei Takeda
  • Eur. J. Org. Chem. 2010, 6643–6650 (2010)
  
  
• Formal Total Syntheses of (+)-Prelaureatin and (+)-Laurallene by Diastereoselective Brook Rearrangement-Mediated [3 + 4] Annulation
• • Michiko Sasaki, Kazuhisa Oyamada, Kei Takeda
  • J. Org. Chem. 75, 3941–3943 (2010)
  
  
• Development of Epoxysilane Rearrangement and its Application to Chirality Transfer
• • Michiko Sasaki, Hidaka Ikemoto, and Kei Takeda
  • Heterocycles, 78, 2919-2941 (2009) (invited)
  
  
• [2,3]-Wittig Rearrangement of Enantiomerically Enriched 3-Substituted 1-Propenyloxy-1-phenyl-2-propen-1-yl Carbanions: Effect of Heteroatoms and Conjugating Groups on Planarization of an α-Oxy-Benzylcarbanion Through a Double Bond
• • Michiko Sasaki, Hidaka Ikemoto, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • Chem. Eur. J. 15, 4663-4666 (2009)
  
  
• Stereoselective Brook Rearrangement-Mediated S_E2' Protonation of a-Hydroxy Allyl Silanes
• • Michiko Sasaki, Yuri Shirakawa, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • Chem. Eur. J. 15, 3363-3366 (2009)
  
  
• Development and Application of Epoxyxilane Rearrangement
• • Michiko Sasaki
  • YAKUGAKU ZASSHI, 128, 1169-1177 (2008) (招待執筆)
  
  
• Diastereoselective Brook Rearrangement-Mediated [3 + 4] Annulation: Application to a Formal Synthesis of (+)-Laurallene
• • Michiko Sasaki, Azusa Hashimoto, Koudai Tanaka, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • Org. Lett. 10, 1803-1806 (2008)
  
  
• Chirality Transfer from Epoxide to Carbanion: Base-Induced Alkylation of O-Carbamoyl Cyanohydrins of β-Silyl-α,β-epoxyaldehyde
• • Michiko Sasaki, Eiji Kawanish, Yuri Shirakawa, Masatoshi Kawahata, Hyuma Masu, Kentaro Yamaguchi, Kei Takeda
  • Eur. J. Org. Chem. 2008, 3061-3064 (2008)
  
  
• Tandem Epoxysilane Rearrangement/Wittig-Type Reactions Using γ-Phosphinoyl- and γ-Phosphonio-α,β-epoxysilane
• • Michiko Sasaki, Mai Horai, Kei Takeda
  • Tetrahedron Lett. 47, 9271-9273 (2006)
  
  
• Epoxysilane Rearrangement: Mechanistic Studies and Synthetic Applications
• • Michiko Sasaki, Kei Takeda
  • J. Synth. Org. Chem., Jpn. 64, 1148-1158 (2006)
  
  
• Epoxysilane Rearrangement Induced by a Carbanion Generated by Conjugate Addition of Enolates of Chloroacetate and α-Chloroacetamides: Formation of Functionalized Cyclopropane Derivatives
• • Noriko Okamoto, Michiko Sasaki, Masatoshi Kawahata, Kentaro Yamaguchi, Kei Takeda
  • Org. Lett. 8, 1889-1891 (2006)
  
  
• Asymmetric [2,3]-Wittig Rearrangement Induced by a Chiral Carbanion Whose Chirality Was Transferred from an Epoxide
• • Michiko Sasaki, Mariko Higashi, Hyuma Masu, Kentaro Yamaguchi, and Kei Takeda
  • Org. Lett. 7, 5913-5915 (2005)
  
  
• γ-p-Toluenesulfonyl-α,β-epoxysilane: A New and Practical Acrolein β-Anion Equivalent
• • Michiko Sasaki, Kei Takeda
  • Org. Lett. 6, 4849-4851 (2004)
  
  
• Stereoselective Construction of Eight-Membered Oxygen Heterocycles by Brook Rearrangement-Mediated [3 + 4] Annulation
• • Yuji Sawada, Michiko Sasaki, Kei Takeda
  • Org. Lett. 6, 2277-2279 (2004)
  
  
• Tandem Base-Promoted Ring-Opening/Brook Rearrangement/Allylic Alkylation of O-Silyl Cyanohydrins of β-Silyl-α,β-epoxyaldehyde: Scope and Mechanism
• • Michiko Sasaki, Eiji Kawanishi, Yoshio Nakai, Tatsuya Matsumoto, Kentaro Yamaguchi, Kei Takeda/font>
  • J. Org. Chem. 68, 9330-9339 (2003)
  
  
• Tandem Base-Promoted Ring-Opening/Brook Rearrangement/Allylic Alkylation of O-Silyl Cyanohydrins of β-Silyl-α,β-epoxyaldehydes
• • Kei Takeda, Eiji Kawanishi, Michiko Sasaki, Yuji Takahashi, Kentaro Yamaguchi
  • Org. Lett. 4, 1511-1514 (2002)