Sasaki Lab | Fukushima Medical University  Japanese/English

Research


  • Steric Course of Deprotonation/Substitution of Chelating/Dipole-Stabilizing-Group-Substituted α-Amino- and α-Oxynitriles


  • Carbanion-Induced [3 + 2]-Annulation of Donor-Acceptor Cyclopropanes


  • Spontaneous Oxygenation of Siloxy-N-Silylketenimines to α-Ketoamides


  • Stereochemical Course of Deprotonation-Acylation of N‐Boc- and N‐Carbamoyl-2-cyano-6-methylpiperidines


  • Enantioselective Synthesis of Allenylenol Silyl Ethers via Chiral Lithium Amide-Mediated Reduction of Ynenoyl Silanes and Their Diels-Alder Reactions


  • Formation of 2-Cyano-2-siloxyvinylallenes via Cyanide-Induced Brook Rearrangement in γ-Bromo-α,β,γ,δ-unsaturated Acylsilanes


  • Enantioselective Synthesis of a-Silylamines by Meerwein-Ponndorf-Verley-Type Reduction of α-Silylimines by a Chiral Lithium Amide


  • Enantiodivergent Deprotonation-Acylation of α-Amino Nitriles


  • Chirality Transfer in Brook Rearrangement-Mediated SE2’ Solvolytic Protonation and Its Use in Estimation of the Propensity for Racemization of the α-Lithiocarbanions of the Substituents


  • Enantioselective Trapping of an α-Chiral Carbanion of Acyclic Nitrile by a Carbon Electrophile


  • Steric Course of the Electrophilc Substitution of Lithiocarbanion Generated from (S,E)-1-Phenylbut-2-en-1-yl Diisopropylcarbamate and Influence of Solvent Effects


  • Enantioselective Synthesis of Siloxyallenes from Alkynoylsilanes by Reduction and Brook Rearrangement and Their Subsequent Trapping in [4 + 2] Cycloaddition


  • Solvent Effects on the Steric Course of [2,3]-Wittig Rearrangement of (S,E)-(3-(allyloxy)prop-1-ene-1,3-diyl)dibenzene and Its Derivatives


  • Formal Total Syntheses of (+)-Prelaureatin and (+)-Laurallene by Diastereoselective Brook Rearrangement-Mediated [3 + 4] Annulation


  • [2,3]-Wittig Rearrangement of Enantiomerically Enriched 3-Substituted 1-Propenyloxy-1-phenyl-2- propen-1-yl Carbanions: Effect of Heteroatoms and Conjugating Groups on Planarization of an α-Oxy-Benzylcarbanion Through a Double Bond


  • Stereoselective Brook Rearrangement-Mediated SE2' Protonation of α-Hydroxy Allyl Silanes


  • Diastereoselective Brook Rearrangement-Mediated [3 + 4] Annulation: Application to a Formal Synthesis of (+)-Laurallene


  • Chirality Transfer from Epoxide to Carbanion: Base-Induced Alkylation of O-Carbamoyl Cyanohydrins of β-Silyl-α,β-epoxyaldehyde


  • Tandem Epoxysilane Rearrangement/Wittig-Type Reactions Using γ-Phosphinoyl- and γ- Phosphonio-α,β-epoxysilane


  • Epoxysilane Rearrangement Induced by a Carbanion Generated by Conjugate Addition of Enolates of Chloroacetate and α-Chloroacetamides: Formation of Functionalized Cyclopropane Derivatives


  • Asymmetric [2,3]-Wittig Rearrangement Induced by a Chiral Carbanion Whose Chirality Was Transferred from an Epoxide


  • γ-p-Toluenesulfonyl-α,β-epoxysilane: A New and Practical Acrolein β-Anion Equivalent


  • Stereoselective Construction of Eight-Membered Oxygen Heterocycles by Brook Rearrangement- Mediated [3 + 4] Annulation


  • Tandem Base-Promoted Ring-Opening/Brook Rearrangement/Allylic Alkylation of O-Silyl Cyanohydrins of β-Silyl-α,β-epoxyaldehyde: Scope and Mechanism


  • Tandem Base-Promoted Ring-Opening/Brook Rearrangement/Allylic Alkylation of O-Silyl Cyanohydrins of β-Silyl-α,β-epoxyaldehyde

    • Metalated O-silyl cyanohydrins of β-Silyl-α,β-epoxyaldehyde have been found to serve as functionalized homoenolate equivalents by a tandem sequence involving a base-promoted ring opening of the epoxide, Brook rearrangement, and alkylation of the resulting allylic anion.